IL-16, Human

IL-16 is a CD8+ T cell-derived cytokine that induces chemotaxis of CD4+ T cells and CD4+ monocytes and eosinophils. Analysis by gel filtration suggests that, under physiological conditions, human IL-16 exists predominantly as a noncovalently linked multimer, but that some IL-16 may exist as a monomer. However, only the multimeric form appears to possess chemotactic activity, suggesting that receptor cross-linking may be required for activity. IL-16 also induces expression of IL-2 receptor (IL-2R) and MHC class II molecules on CD4+ T cells. Human and murine IL-16 show significant cross-species reactivity.

产品编号	Z02196
规格	10 μg 50 μg 1 mg 定制报价
数量
价格	￥1200


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产品简介

Species

Human

Protein Construction

IL-16 (Met1203-Ser1332)
Accession # Q14005

Purity

> 95% as analyzed by SDS-PAGE

Endotoxin Level

< 1 EU/μg of protein by LAL method

Expression System

E. coli

Apparent Molecular Weight

18-20 kDa, on SDS-PAGE under reducing conditions.

Formulation

Lyophilized from a 0.2 μm filtered solution in 20 mM PB, 150 mM NaCl, pH 7.0.

Reconstitution

It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in distilled water up to 100 µg/ml.

Storage & Stability

Upon receiving, this product remains stable for up to 6 months at -70°C or -20°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. Avoid repeated freeze-thaw cycles.

技术背景

Target Background

IL-16 is a CD8⁺ T cell-derived cytokine that induces chemotaxis of CD4⁺ T cells and CD4⁺ monocytes and eosinophils. Analysis by gel filtration suggests that, under physiological conditions, human IL-16 exists predominantly as a noncovalently linked multimer, but that some IL-16 may exist as a monomer. However, only the multimeric form appears to possess chemotactic activity, suggesting that receptor cross-linking may be required for activity. IL-16 also induces expression of IL-2 receptor (IL-2R) and MHC class II molecules on CD4⁺ T cells. Human and murine IL-16 show significant cross-species reactivity.

Synonyms

IL16; LCF; NPRprIL-16; IL-16; interleukin 16

For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.