Species |
Human |
Protein Construction |
Poly-His |
CLDN18.2 (Met1-Lys207) Accession # P56856-2 |
N-term |
C-term |
|
Purity |
> 80% as analyzed by SDS-PAGE |
Biological Activity |
Immobilized CLDN18.2, His, Human (Cat. No.: Z03504) at 1.0 μg/mL (100μl/well). Dose response curve for anti-Claudin 18.2 Antibody with the EC50 of 13.75ng/mL determined by ELISA. |
Expression System |
Insect Cells |
Theoretical Molecular Weight |
27.7 kDa |
Formulation |
Supplied as a solution in 50 mM Hepes, 500 mM NaCl, 10% glycerol, 0.2% DDM, 0.04% CHS, pH 7.5. |
Concentration |
Please refer to the COA for the specific lot. |
Storage & Stability |
Upon receiving, this product remains stable for up to 6 months at -80°C. Please avoid repeated freeze-thaw cycles. |
Lane BSA: 2 μg BSA
Lane R: 2 μg CLDN18.2, reducing(R), no heat treatment before loading
> 90% as analyzed by SDS-PAGE
Immobilized CLDN18.2, His, Human (Cat. No.: Z03504) at 1μg/mL (100μl/well). Dose response curve for anti-Claudin 18.2 Antibody with the EC50 of 13.75ng/mL determined by ELISA.
Target Background |
Claudin-18 is a protein that in humans is encoded by the CLDN18 gene. CLDN18 belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells. The Expression of Isoform A2 (CLDN18.2) is restricted to the stomach mucosa where it is predominantly observed in the epithelial cells of the pit region and the base of the gastric glands including exocrine and endocrine cells (at protein level). CLDN18.2 is founded to be abundant in gastric tumors, Experimental antibody IMAB362 targets Claudin 18.2 to help treat gastric cancers. |
Synonyms |
Claudin-18; CLDN18; SFTA5; SFTPJ; claudin 18 |
For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.