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Phosphorylation of LSD1 by PLK1 promotes its chromatin release during mitosis

Cell Biosci. 2017-01; 
PengBin, ShiRuifeng, JiangWeiwei, DingYue-He, DongMeng-Qiu, ZhuWei-Guo, XuXin
Products/Services Used Details Operation
… Rabbit polyclonal anti-H3 antibody (#9715) was from Cell Signaling Technology. Mouse monoclonal antibody against GST (A00865) was from GenScript Corporation. Mouse monoclonal anti-FLAG M2 (F1804) was from Sigma …

摘要

Lysine-specific histone demethylase 1 (LSD1) modulates chromatin status through demethylation of H3K4 and H3K9. It has been demonstrated that LSD1 is hyperphosphorylated and dissociates from chromatin during mitosis. However， the molecular mechanism of LSD1 detachment is unknown.

关键词

Chromatin release，Lysine-specific demethylase LSD1，Mitosis，PLK1，Phosphoryla