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Bacterial type III effector protein HopQ inhibits melanoma motility through autophagic degradation of vimentin

Cell Death Dis. 2020-04-01; 
Seung-Ho Park, Sung-Jin Yoon, Song Choi, Jun-Seob Kim, Moo-Seung Lee, Seon-Jin Lee, Sang-Hyun Lee, Jeong-Ki Min, Mi-Young Son, Choong-Min Ryu, Jiyun Yoo, Young-Jun Park
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摘要

Malignant melanoma is a fatal disease that rapidly spreads to the whole body. Treatments have limited efficiency owing to drug resistance and various side effects. Pseudomonas syringae pv. tomato (Pto) is a model bacterial pathogen capable of systemic infection in plants. Pto injects the effector protein HopQ into the plant cytosol via a type III secretion machinery and suppresses the host immunity. Intriguingly, host plant proteins regulated by HopQ are conserved even in humans and conferred in tumor metastasis. Nevertheless, the potential for HopQ to regulate human cancer metastasis was unknown. In this study, we addressed the suitability of HopQ as a possible drug against melanoma metastasis. In melanoma cel... More

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