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Dietary Isoflavones Alter Gut Microbiota and Lipopolysaccharide Biosynthesis to Reduce Inflammation

Gut Microbes. 2022-01; 
Sudeep Ghimire, Nicole M Cady, Peter Lehman, Stephanie R Peterson, Shailesh K Shahi, Faraz Rashid, Shailendra Giri, Ashutosh K Mangalam
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Endotoxin Detection & Removal System … The fecal lysate was thawed and endotoxin levels were quantified in 10μl of filtrates using ToxinSensor Chromogenic LAL Endotoxin Assay Kit (Cat. No. L00350 GenScript NJ) following … Get A Quote

摘要

The etiopathogenesis of multiple sclerosis (MS) is strongly affected by environmental factors such as diet and the gut microbiota. An isoflavone-rich (ISO) diet was previously shown to reduce the severity of MS in the animal model experimental autoimmune encephalomyelitis (EAE). Translation of this concept to clinical trial where dietary isoflavones may be recommended for MS patients will require preliminary evidence that providing the isoflavone-rich diet to people with MS (PwMS) who lack phytoestrogen-metabolizing bacteria has beneficial effects. We have previously shown that the gut microbiota of PwMS resembles the gut microbiota of mice raised under a phytoestrogen-free (phyto-free) diet in that it lacks ph... More

关键词

EAE, Gut microbiota, diet, isoflavones, lipopolysaccharides