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Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection

Science. 2021-01; 
Jennifer M Dan, Jose Mateus, Yu Kato, Kathryn M Hastie, Esther Dawen Yu, Caterina E Faliti, Alba Grifoni, Sydney I Ramirez, Sonya Haupt, April Frazier, Catherine Nakao, Vamseedhar Rayaprolu, Stephen A Rawlings, Bjoern Peters, Florian Krammer, Viviana Simon, Erica Ollmann Saphire, Davey M Smith, Daniela Weiskopf, Alessandro Sette, Shane Crotty
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Recombinant Antibody Expression Antigens included recombinant SARS-CoV-2 RBD protein, recombinant Spike protein, and recombinant Nucleocapsid protein (GenScript Z03488) Get A Quote

摘要

Understanding immune memory to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical for improving diagnostics and vaccines and for assessing the likely future course of the COVID-19 pandemic. We analyzed multiple compartments of circulating immune memory to SARS-CoV-2 in 254 samples from 188 COVID-19 cases, including 43 samples at ≥6 months after infection. Immunoglobulin G (IgG) to the spike protein was relatively stable over 6+ months. Spike-specific memory B cells were more abundant at 6 months than at 1 month after symptom onset. SARS-CoV-2-specific CD4 T cells and CD8 T cells declined with a half-life of 3 to 5 months. By studying antibody, memory B cell, CD4 T cell, and CD8 T cell me... More

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